For everyone’s eyes and sanity while navigating this guide please try to not quote the entire original post. If you have a question or something to add or address please trim it down so you are replying to only the specific point you are addressing.
I will use this spoiler to estimate individual print runs by set. This will be updated and refined over time. Initial estimates are wild ass guesses that attempt to mesh with the chart above. I’ll leave my initial WOTC estimates unspoiled as I assume they will garner the most interest.
My WOTC estimates (All languages)
1 Base Set - 3 B Cards
2 Jungle - 1.75 B Cards
3 Fossil - 1.75 B Cards
4 Base Set 2 - 600 M Cards
5 Team Rocket - 1.1 B Cards
6 Gym Heroes - 850 M Cards
7 Gym Challenge - 850 M Cards
8 Neo Genesis - 700 M Cards
9 Neo Discovery - 700 M Cards
10 Neo Revelation - 700 M Cards - 12 Billion end of 2001 checkpoint ( 1.2 B per set avg.)
11 Neo Destiny
12 Legendary Collection
13 Expedition Base Set
14 Aquapolis
15 Skyridge
Rest of the Sets
16 EX Ruby & Sapphire
17 EX Sandstorm
18 EX Dragon
19 EX Team Magma vs Team Aqua
20 EX Hidden Legends
21 EX FireRed & LeafGreen
22 EX Team Rocket Returns
23 EX Deoxys
24 EX Emerald
25 EX Unseen Forces
26 EX Delta Species
27 EX Legend Maker
28 EX Holon Phantoms
29 EX Crystal Guardians
30 EX Dragon Frontiers
31 EX Power Keepers
32 Diamond & Pearl
33 Mysterious Treasures
34 Secret Wonders
35 Great Encounters
36 Majestic Dawn
37 Legends Awakened
38 Stormfront
39 Platinum
40 Rising Rivals
41 Supreme Victors
42 Arceus
43 HeartGold & SoulSilver
44 Unleashed
45 Undaunted
46 Triumphant
47 Call of Legends
48 Black & White
49 Emerging Powers
50 Noble Victories
51 Next Destinies
52 Dark Explorers
53 Dragons Exalted
54 Boundaries Crossed
55 Plasma Storm
56 Plasma Freeze
57 Plasma Blast
58 Legendary Treasures 21.5 B checkpoint (9.5 B since last, 200M card per set avg)
59 XY
60 Flashfire
61 Furious Fists
62 Phantom Forces
63 Primal Clash
64 Roaring Skies
65 Ancient Origins
66 BREAKthrough
67 BREAKpoint
68 Generations
69 Fates Collide
70 Steam Siege
71 Evolutions
72 Sun & Moon - 23.6 billion through March 2017 (2.1 B since last, 150 M per set avg)
73 Guardians Rising
74 Burning Shadows
75 Shining Legends
76 Crimson Invasion
77 Ultra Prism
78 Forbidden Light